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The Effect of Nafarelin Acetate

  We advised the access of androgens on amiable prostatic hyperplasia, application nafarelin acetate, a almighty luteinizing-hormone–releasing hormone agonist, to accomplish capricious androgen denial in men with amiable prostatic hyperplasia. Nine patients with bladder-outlet obstruction due to amiable prostatic hyperplasia were advised with subcutaneous nafarelin acetate (400 μg per day) in an accessible balloon for six months. In all patients, serum testosterone decreased to alter levels. Objective observations included uroflowmetry, altitude of balance urine volume, assurance of prostatic admeasurement by ultrasonography, and prostatic biopsy.

  In all patients, the prostate regressed to a beggarly (±SEM) of 75.8±3 percent of the antecedent admeasurement (range, 52 to 86; P<0.005); the corruption accomplished a plateau afterwards four months. Morphologic assay of biopsy specimens showed corruption of glandular epithelium. Three of nine patients had analytic advance with treatment. Six months afterwards the abeyance of treatment, claret testosterone levels had alternate to accustomed and the admeasurement of the prostate had added to 99±5.5 percent of the antecedent size.